Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relapsing polychondritis: an ultrastructural study

K Hashimoto, C R Arkin, A H Kang

    Arthritis and Rheumatism
    |January 1, 1977
    PubMed
    Summary

    Electron microscopy revealed dense granules and vesicles around damaged chondrocytes in relapsing polychondritis. These may be lysosomes contributing to cartilage inflammation and proteoglycan loss.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The effects of interleukin-18 on rat articular chondrocytes: a study of mRNA expression and protein synthesis of proinflammatory substances.

    Clinical and experimental immunology·2007
    Same author

    The isozyme-specific effects of cyclooxygenase-deficiency on bone in mice.

    Bone·2006
    Same author

    Efficacy of modified recombinant type II collagen in modulating autoimmune arthritis.

    Arthritis and rheumatism·2004
    Same author

    Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B.

    Biochemistry·2004
    Same author

    The roles of interleukin-18 in collagen-induced arthritis in the BB rat.

    Clinical and experimental immunology·2004
    Same author

    Immunogenicity of recombinant type IX collagen in murine collagen-induced arthritis.

    Arthritis and rheumatism·2002

    Area of Science:

    • * Electron microscopy of cartilage.
    • * Cell biology and pathology.

    Background:

    • * Relapsing polychondritis is a condition affecting cartilage.
    • * Understanding the cellular mechanisms of cartilage damage is crucial.

    Observation:

    • * Electron microscopy of ear cartilage from a relapsing polychondritis patient.
    • * Chondrocytes were surrounded by numerous dense granules and vesicles.
    • * These structures resembled matrix vesicles or lysosomes.

    Findings:

    • * Granules and vesicles appeared to bud from or pinch off cytoplasmic processes in less damaged cells.
    • * Minimal calcification of these granules was observed.
    • * Severely damaged chondrocytes showed an admixture of granules and cytoplasmic organelles.

    Implications:

    • * Dense granules are likely lysosomal, contributing to inflammation.
    • * These cellular changes may reduce cartilage proteoglycan content.
    • * Further research into lysosomal roles in relapsing polychondritis is warranted.

    Related Experiment Videos