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Plasma insulin concentration during physiological variations in immunoreactive plasma secretin
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|July 1, 1976
Summary
Secretin, a hormone, does not affect fasting insulin or glucose levels in non-diabetic individuals. Studies show no change in blood glucose or insulin after secretin stimulation or infusion.
Area of Science:
- Endocrinology
- Gastroenterology
- Metabolic Research
Background:
- Secretin is a gastrointestinal hormone.
- Its role in glucose and insulin regulation is not fully understood.
Purpose of the Study:
- To investigate the effect of endogenous and exogenous secretin on fasting plasma insulin and glucose concentrations.
- To determine if secretin influences insulin secretion in normal subjects.
Main Methods:
- Administered hydrochloric acid and saline intragastrically to non-diabetic subjects.
- Measured plasma secretin, insulin, and glucose concentrations.
- Infused pure natural porcine secretin intravenously at varying doses.
Main Results:
- Intragastric acid significantly increased plasma secretin but did not affect insulin or glucose.
- Saline control showed no changes in secretin, insulin, or glucose.
- Intravenous secretin infusion did not alter fasting plasma insulin or glucose levels.
Conclusions:
- Endogenous secretin, stimulated by gastric acid, does not impact insulin or glucose.
- Exogenous secretin administration has no discernible effect on insulin secretion in fasting normal individuals.