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Related Experiment Videos

Baclofen-induced bronchoconstriction

P V Dicpinigaitis1, D M Nierman, A Miller

  • 1Division of Pulmonary and Critical Care Medicine, Mount Sinai School of Medicine, New York, NY.

The Annals of Pharmacotherapy
|July 1, 1993
PubMed
Summary
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Oral baclofen may trigger acute bronchospasm and increased bronchial reactivity in asthma patients. Clinicians should consider this potential adverse effect, particularly in those with asthma.

Area of Science:

  • Pharmacology
  • Pulmonology
  • Clinical Medicine

Background:

  • Baclofen, a gamma-aminobutyric acid (GABA) agonist, is typically studied for its potential to reduce airway responsiveness.
  • Animal studies suggest baclofen may have bronchodilatory effects.

Observation:

  • A 46-year-old male asthmatic experienced dyspnea and chest tightness after a single 40 mg oral dose of baclofen, with decreased airflow on pulmonary function tests.
  • A 33-year-old female with a history of exercise-induced asthma showed bronchial hyperresponsiveness to methacholine two hours after ingesting 40 mg of baclofen, despite a prior negative challenge.

Findings:

  • Two separate cases indicate that oral baclofen can induce acute bronchospasm and increase bronchial reactivity in individuals with asthma.
  • The observed responses appear paradoxical given baclofen's GABA-agonist properties and some preclinical data.

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Implications:

  • These findings highlight a potential, previously unrecognized adverse effect of baclofen in asthmatic patients.
  • Clinicians should exercise caution and consider baclofen-induced bronchospasm in asthmatic individuals presenting with respiratory symptoms after baclofen administration.
  • Further research is warranted to elucidate the mechanism behind this paradoxical airway response.