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Related Experiment Videos

Inflammatory myofibroblastic tumor in children

A K Souid1, M C Ziemba, A S Dubansky

  • 1Department of Pediatrics, SUNY Health Science Center, Syracuse 13210.

Cancer
|September 15, 1993
PubMed
Summary

Inflammatory myofibroblastic (IMF) tumors can present as solid masses with significant inflammation. Early recognition and surgical resection are key for successful treatment and preventing recurrence in pediatric cases.

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Area of Science:

  • Pediatric Oncology
  • Surgical Pathology

Background:

  • Inflammatory myofibroblastic (IMF) tumors are rare neoplasms with unpredictable behavior.
  • Accurate preoperative diagnosis and understanding the natural history are crucial for effective management.

Observation:

  • Two pediatric cases of IMF tumor are presented: one originating in the mesentery and another in the lung.
  • The mesenteric IMF tumor presented with systemic inflammatory signs including fever, growth impairment, thrombocytosis, and anemia, which resolved post-surgery but recurred later.
  • The lung IMF tumor was initially indistinguishable from pulmonary sequestration on radiological imaging.

Findings:

  • Complete surgical resection led to resolution of symptoms and normalization of laboratory values in both cases.
  • Recurrence of the mesenteric IMF tumor was successfully treated with a second surgery, with no disease recurrence for 30 months.

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  • The lung IMF tumor showed no recurrence 18 months after resection.

    • Implications:

    • IMF tumors should be suspected in pediatric solid tumors associated with chronic inflammatory responses.
    • Consider IMF tumor in the differential diagnosis of pulmonary sequestration.
    • Prompt surgical intervention and vigilant follow-up are essential for managing pediatric IMF tumors.