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Long-lasting allergic patch test reaction caused by gold

T Aro1, L Kanerva, R Häyrinen-Immonen

  • 1Institute of Occupational Health, Helsinki, Finland.

Contact Dermatitis
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

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Gold allergy, though rare, can be diagnosed using specific patch tests and in vitro blast transformation tests. However, these gold allergy tests may cause prolonged reactions requiring further study.

Area of Science:

  • Dermatology
  • Immunology
  • Allergology

Background:

  • Allergic contact dermatitis from gold is infrequently reported.
  • Gold allergy diagnosis often relies on patch testing, which can elicit persistent reactions.

Observation:

  • A case study investigated gold allergy in a patient with dental gold crowns.
  • Evaluated patch tests, immunohistochemistry, electron microscopy, and blast transformation reactions in a sensitized patient and a control.

Findings:

  • Positive patch test reactions were observed with gold sodium thiosulfate, auranofin, and gold sodium thiomalate.
  • Delayed down-regulation of allergic reactions was noted in gold patch tests compared to other allergens.
  • The patient showed positive in vitro blast transformation responses to most gold salts, unlike the control subject.

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Implications:

  • Gold sodium thiosulfate, auranofin, and gold sodium thiomalate are viable patch test agents for gold allergy.
  • In vitro blast transformation offers an alternative diagnostic method for gold allergy.
  • Further research is needed to understand the slow down-regulation kinetics of allergic gold patch test reactions.