Circadian variation of bronchial caliber and antigen-induced late asthmatic response

To study whether circadian variation of bronchial caliber participates in causing late asthmatic response (LAR), house-dust inhalation was made at 10 AM and 6 PM on separate days in 6 house-dust-sensitive asthmatic children aged 8 to 13 years. Bronchial obstruction was assessed through measurements of FEV1 at 4-h intervals from 24 h before to 24 h after the inhalation. The LAR, which is a 15 percent or greater decrease in FEV1 from the value at the same hour of the previous day, occurred 4 h or later after the inhalation in all challenges. The mean (+/- SD) time to the occurrence of the lowest FEV1 (maximum LAR) following the morning inhalation was 14.7 +/- 2.1 h versus 10.0 +/- 2.2 h following the evening inhalation (p < 0.05). Regardless of the hour of inhalation, FEV1 after the inhalation was lowest or near-lowest at 2 AM in all. Therefore, the maximum LAR was indistinguishable from the trough of further amplified circadian variation in FEV1 following the inhalation. These findings suggest that the downward arm of circadian variation may partially participate in causing the LAR.