Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mismatch recognition in chromosomal interactions and speciation

M Radman1, R Wagner

  • 1Institute Jacques Monod, CNRS-Université Paris 7, France.

Chromosoma
|June 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide association analysis suggests novel loci for Hashimoto's thyroiditis.

Journal of endocrinological investigation·2018
Same author

Longitudinal development of obesity in the post-Fontan population.

European journal of clinical nutrition·2015
Same author

Toll-like receptor 4 plays significant roles during allergic rhinitis.

Allergologia et immunopathologia·2014
Same author

[How much do we know about human brucellosis?].

Zeitschrift fur Rheumatologie·2009
Same author

DNA repair systems and bacterial evolution.

Cold Spring Harbor symposia on quantitative biology·2003
Same author

The rise and fall of mutator bacteria.

Current opinion in microbiology·2001

Proteins mediating DNA recombination and mismatch repair guide homologous chromosome interactions during meiosis. As DNA sequences diverge, these interactions decrease, potentially leading to reproductive isolation between species.

Area of Science:

  • Genetics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Homologous chromosome interactions are crucial for accurate meiosis.
  • Proteins involved in DNA recombination and mismatch repair mediate these interactions.

Purpose of the Study:

  • To investigate the role of recombination and mismatch repair proteins in homologous chromosome interactions during meiosis.
  • To understand how sequence divergence affects these interactions and potentially leads to reproductive isolation.

Main Methods:

  • The study focuses on the functional roles of key proteins involved in DNA recombination and mismatch repair.
  • It examines how these proteins facilitate or inhibit homologous chromosome pairing and exchange.

Main Results:

Related Experiment Videos

  • Recombination proteins promote homologous chromosome pairing by facilitating homology search and strand exchange.
  • Mismatch repair proteins act as editors, disrupting associations with mismatched base pairs.
  • Increasing sequence polymorphism in homologous chromosomes inhibits recombinational interactions.

Conclusions:

  • Decreased homologous interactions contribute to maintaining chromosome integrity.
  • Reduced interactions during meiosis can lead to sterile meioses, driving reproductive isolation and speciation.