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A seroimmunological analysis of Down syndrome
M Oda1, R Hakamada, K Ono
1Department of Maternal and Child Health, University of Tokyo, School of Health Sciences, Japan.
Gerontology
|January 1, 1993
Summary
This study investigated immune function in Down syndrome (DS), finding altered antibody levels and elevated specific glycoproteins. These markers, along with reduced helper T cells, show potential for distinguishing DS patients.
Area of Science:
- Immunology
- Clinical Chemistry
- Genetics
Background:
- Down syndrome (DS) is associated with immune dysregulation.
- Previous studies suggest varied immunological profiles in DS patients.
Purpose of the Study:
- To investigate immunological function and serological aspects in institutionalized Down syndrome patients.
- To identify potential biomarkers for differentiating DS patients from healthy controls.
Main Methods:
- Sera from 36 DS patients and controls were analyzed for antibody levels against common viruses.
- Six tumor markers, including alpha-1-acid glycoprotein (alpha 1-AGP), were quantified.
- Flow cytometry was used to assess helper T cell levels.
Main Results:
- Antibody levels against mumps and measles were lower in DS patients compared to controls.
- Serum concentrations of alpha-1-acid glycoprotein (alpha 1-AGP) and immunosuppressive acidic protein were significantly higher in DS patients.
- A discriminant function based on tumor markers achieved 92.3% sensitivity in distinguishing DS patients.
- Helper T cell levels were found to be lower in DS patients.
Conclusions:
- Down syndrome patients exhibit specific alterations in humoral and cellular immunity.
- Elevated alpha-1-acid glycoprotein and related markers may serve as potential biomarkers for DS.
- Further research is warranted to explore the clinical implications of these immunological findings in DS.