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Zinc binding: a difference between human and bovine milk

C D Eckhert, M V Sloan, J R Duncan

    Science (New York, N.Y.)
    |February 25, 1977
    PubMed
    Summary
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    Zinc in cow's milk binds to large molecules, while zinc in human milk binds to small molecules. This difference in zinc binding may explain why human milk helps acrodermatitis enteropathica, unlike cow's milk.

    Area of Science:

    • Biochemistry
    • Nutritional Science
    • Human Health

    Background:

    • Acrodermatitis enteropathica is a genetic disorder of zinc metabolism.
    • Dietary zinc is crucial for human health, but its bioavailability can vary.
    • Cow's milk and human milk are common dietary sources of zinc.

    Purpose of the Study:

    • To investigate the differences in zinc binding and distribution between cow's milk and human milk.
    • To explore the potential impact of these differences on zinc absorption and metabolism.
    • To understand the implications for managing acrodermatitis enteropathica.

    Main Methods:

    • Gel chromatography was used to analyze the molecular weight distribution of zinc in both milk types.
    • Comparative analysis of zinc-associated fractions was performed.

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    Main Results:

    • Most zinc in cow's milk was found in high-molecular-weight fractions.
    • Most zinc in human milk was associated with low-molecular-weight fractions.
    • This indicates a species-specific difference in zinc-binding ligands.

    Conclusions:

    • The distinct molecular associations of zinc in human versus cow's milk likely influence zinc bioavailability.
    • This difference may explain the therapeutic efficacy of human milk in acrodermatitis enteropathica.
    • Targeting zinc-binding ligands could offer new strategies for managing zinc deficiencies.