Related Experiment Videos
Neuroendocrine and substrate responses to altered brain 5-HT activity during prolonged exercise to fatigue
S P Bailey1, J M Davis, E N Ahlborn
1Department of Exercise Science, School of Public Health, University of South Carolina, Columbia 29208.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1993
Summary
Altering brain serotonin activity impacts exercise endurance in rats. Serotonin agonists reduced run time, while antagonists increased it, affecting energy substrate levels.
Area of Science:
- Exercise Physiology
- Neuropharmacology
- Biochemistry
Background:
- Brain serotonergic (5-hydroxytryptamine, 5-HT) activity influences endurance performance.
- Potential mechanisms include neurochemical, hormonal, and substrate alterations.
Purpose of the Study:
- To investigate the effects of pharmacological manipulation of 5-HT activity on exercise run time to exhaustion in rats.
- To examine associated changes in neurochemical, hormonal, and substrate levels.
Main Methods:
- Rats were administered quipazine dimaleate (5-HT agonist), LY 53857 (5-HT antagonist), or vehicle before treadmill running.
- Samples were collected at rest, 1 hour of exercise, and exhaustion for analysis.
Main Results:
- LY 53857 increased, while quipazine dimaleate decreased, time to exhaustion.
- Quipazine dimaleate altered plasma glucose, glycogen, and free fatty acid concentrations at fatigue.
- Brain 5-HT and dopamine metabolite levels showed dynamic changes during exercise, modulated by the drugs.
Conclusions:
- Pharmacological modulation of 5-HT significantly impacts endurance capacity in rats.
- These effects are associated with changes in energy metabolism and central neurotransmitter dynamics.