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Related Experiment Videos

CD44 expression in normal and inflamed skin

N S Penneys1

  • 1Division of Dermatology, Saint Louis University School of Medicine, Mo.

Journal of Cutaneous Pathology
|June 1, 1993
PubMed
Summary
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CD44, a hyaluronate receptor, is found on skin eccrine coil cells. Its expression changes with inflammation or injury, suggesting roles in cell adhesion and keratinocyte behavior, but its function in sweat production remains unclear.

Area of Science:

  • Dermatology
  • Cell Biology
  • Immunology

Background:

  • CD44 is identified as the primary cell surface receptor for hyaluronate.
  • In healthy skin, CD44 expression is localized to the cell membrane of eccrine coil cells, showing asymmetric distribution.

Purpose of the Study:

  • To investigate the expression patterns of CD44 in both normal and pathological skin conditions.
  • To explore the potential roles of CD44 in cellular adhesion, keratinocyte proliferation, and eccrine sweat production.

Main Methods:

  • Immunohistochemical analysis of CD44 expression in skin tissue samples.
  • Comparison of CD44 distribution in non-inflamed skin versus skin with inflammatory or neoplastic processes.

Main Results:

Related Experiment Videos

  • CD44 expression is restricted to the non-luminal membrane of eccrine coil cells in normal skin.
  • In pathological skin, CD44 expression becomes widespread on keratinocytes and infiltrating lymphocytes.
  • CD44 may indicate a role in cellular adhesion and identify proliferating keratinocytes responding to injury.

    • Conclusions:

    • CD44's stable presence on eccrine secretory cells suggests an uncharacterized function in eccrine sweat generation.
    • CD44's altered expression in pathological skin highlights its involvement in inflammatory and neoplastic processes and cell-cell interactions.