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[Changes in transaminase before and after tonsillectomy]

Y Chiba1

  • 1Department of Otolaryngology, Teikyo University School of Medicine, Tokyo.

Nihon Jibiinkoka Gakkai Kaiho
|July 1, 1993
PubMed
Summary
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Tonsillectomy patients often show high transaminase levels, which improve post-surgery. This study suggests elevated liver enzymes (GOT, GPT) in these patients may stem from other organs, not the tonsils themselves.

Area of Science:

  • Hepatology
  • Otorhinolaryngology

Context:

  • Patients undergoing palatine tonsillectomy for chronic tonsillitis or hypertrophy frequently exhibit postoperative changes in laboratory values.
  • Elevated serum transaminase levels, specifically serum glutamate oxaloacetate transaminase (GOT) and serum glutamate pyruvate transaminase (GPT), are observed preoperatively in some patients.

Purpose:

  • To investigate the postoperative changes in serum transaminase levels (GOT and GPT) in patients following palatine tonsillectomy.
  • To explore the potential source of elevated transaminase levels in patients undergoing tonsillectomy, differentiating between tonsillar origin and other organs.

Summary:

  • This study analyzed 17 patients with abnormal preoperative transaminase levels before tonsillectomy.
  • Preoperatively, all patients had abnormal serum GPT, and half had abnormal serum GOT, with GPT levels consistently higher than GOT.

Related Experiment Videos

  • Post-tonsillectomy, both GOT and GPT levels normalized within 11 and 25 days, respectively.
  • Intracellular transaminase activity in palatine tonsils did not appear to significantly elevate serum levels.
  • The recovery pattern differed from that seen in fatty liver disease, suggesting extratonsillar origins for elevated transaminases.

    • Impact:

    • Provides evidence that elevated serum transaminases in tonsillectomy patients may not originate from the palatine tonsils.
    • Suggests further investigation into other organs as the source of elevated transaminases in this patient population.
    • Contributes to understanding the differential diagnosis and management of abnormal liver enzyme levels in patients undergoing head and neck surgery.