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[Clinical observation of acute otitis media in children]
1Department of Otolaryngology, Suibaragou Hospital, Niigata.
Insights
This study found that a cefaclor and fosfomycin otic solution effectively treated acute otitis media in 99% of pediatric patients, with no reported side effects. Long-term follow-up indicated its usefulness in managing this common ear infection.
Area of Science:
- Otolaryngology
- Pediatric Infectious Diseases
- Pharmacology
Context:
- Acute otitis media (AOM) is a common pediatric infection requiring effective treatment.
- Myringotomy was indicated for severe tympanic membrane erythema and swelling in the study cohort.
- Evaluating treatment efficacy requires assessing clinical outcomes and long-term prognosis.
Purpose:
- To investigate the efficacy and safety of a combined cefaclor and fosfomycin otic solution for AOM in children.
- To correlate early treatment findings with the clinical course and prognosis of AOM over one year.
- To assess treatment effectiveness based on tympanic membrane healing stages.
Summary:
- A 10-day course of cefaclor and fosfomycin otic solution was administered to 81 children with AOM.
- Treatment effectiveness was evaluated using tympanic membrane status (cured, recovered, unchanged) and clinical follow-up.
- Radiographic examination assessed mastoid pneumatization, paranasal sinuses, and adenoid vegetation.
Impact:
- The cefaclor and fosfomycin combination demonstrated high efficacy (99%) and an excellent safety profile.
- Prolonged AOM courses were associated with radiographic findings of mastoid pneumatization and paranasal sinus involvement.
- This combination therapy is deemed extremely useful for managing pediatric AOM.
Abstract:
The efficacy of a combination of cefaclor and fosfomycin otic solution was investigated in 81 children with acute otitis media, who needed myringotomy for severe erythema and swelling of the tympanic membrane. The patients were followed up for one year to investigate correlations between test findings of early treatment and both clinical course and prognosis. These drugs were used for 10 days, and the effects of combined use were evaluated from findings in the tympanic membrane after the 10-day period. Three stages were assessed; cured, recovered and unchanged. In cured and recovered cases, the administration was evaluated to be effective. Within 2 weeks after the start of treatment, views of the ears, nose and epipharynx were roentgenographically examined for shadows of mastoid pneumatization and the paranasal sinuses, and the presence or absence of adenoid vegetation. After the antibiotic administration, the patients were instructed to visit us at least once every 3 months to rule out recurrence of acute otitis media and otitis media with effusion (possibly occurring one year after treatment). The following results were obtained. 1. The two drug combination was effective in 99% of patients, produced no side effects, and was deemed extremely useful. 2. The course of acute otitis media tended to be significantly prolonged in patients with mastoid pneumatization and paranasal sinus shadows as revealed by roentgenography.(ABSTRACT TRUNCATED AT 250 WORDS)