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The pigment dispersion syndrome

B Becker, D H Shin, D G Cooper

    American Journal of Ophthalmology
    |February 1, 1977
    PubMed
    Summary

    Pigment dispersion syndrome is not a high glaucoma risk factor. Specific HLA antigens (HLA-B13, Bw17) are linked to pigment dispersion syndrome and pigmentary glaucoma, suggesting a distinct genetic basis for pigmentary glaucoma.

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    Area of Science:

    • Ophthalmology
    • Genetics
    • Immunology

    Background:

    • Pigment dispersion syndrome (PDS) affects individuals with and without glaucoma.
    • The role of PDS as a risk factor for glaucoma development requires further investigation.
    • Human Leukocyte Antigen (HLA) associations with ocular conditions are of significant interest.

    Purpose of the Study:

    • To investigate the prevalence of PDS in relation to glaucoma.
    • To examine the association between specific HLA antigens and PDS.
    • To determine if pigmentary glaucoma has a distinct genetic profile compared to other glaucoma types.

    Main Methods:

    • Prevalence of PDS was assessed in subjects with and without glaucoma.
    • HLA antigen typing was performed on subjects with and without PDS.
    • Statistical analysis compared HLA antigen frequencies between groups, including patients with pigmentary glaucoma, PDS without glaucoma, primary open-angle glaucoma, and the general population.

    Main Results:

    • PDS was observed in 10% of subjects, irrespective of glaucoma status, indicating it's not a high glaucoma risk factor.
    • HLA-B7 antigen was less prevalent, while HLA-B13 and Bw17 antigens were significantly more prevalent in individuals with PDS.
    • Specific combinations of HLA-B12 with HLA-B13 or Bw17 were notably higher in pigmentary glaucoma patients compared to other groups.

    Conclusions:

    • PDS alone does not appear to be a significant risk factor for glaucoma development.
    • Specific HLA antigens (HLA-B13, Bw17) are strongly associated with pigment dispersion syndrome.
    • Pigmentary glaucoma exhibits a distinct genetic predisposition, differing from primary open-angle glaucoma, likely due to specific HLA antigen combinations.

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