Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Direct gallstone dissolution therapy with GS-100]

F Yamamoto1, H Igimi

  • 1Yamamoto Surgical Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Very high resolution single pass HLA genotyping using amplicon sequencing on the 454 next generation DNA sequencers: Comparison with Sanger sequencing.

Human immunology·2015
Same author

Altered expression of dermokine in skin disorders.

Journal of the European Academy of Dermatology and Venereology : JEADV·2012
Same author

Amending reduced fish-meal feeds with marine lecithin, but not soy lecithin, improves the growth of juvenile cobia and may attenuate heightened responses to stress challenge.

Journal of animal physiology and animal nutrition·2011
Same author

Blood cardioplegia serves as a bicarbonate donor to the myocardium during ischemia: effects of anoxia and hypercapnia on acid-base characteristics of blood cardioplegic solution.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes·2011
Same author

[Management of mediastinitis and preventions of perioperative nosocomial infection after cardiovascular surgery].

Kyobu geka. The Japanese journal of thoracic surgery·2010
Same author

[Surgical repair of extracardiac unruptured aneurysm of the sinus of Valsalva].

Kyobu geka. The Japanese journal of thoracic surgery·2008
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

A new drug, GS-100, combines d-limonene with medium-chain monoglyceride (MCM) for effective cholesterol gallstone dissolution. This safer, non-invasive therapy shows promise for treating gallstones and bile duct stones.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Medical Devices

Background:

  • Gallstones, particularly cholesterol stones, pose a significant clinical challenge.
  • Current non-invasive therapies like methyl tert-butyl ether (MTBE) dissolution and extracorporeal shock wave lithotripsy (ESWL) have limitations.
  • There is a need for safer and more effective non-invasive gallstone dissolution agents.

Purpose of the Study:

  • To introduce and evaluate GS-100, a novel direct dissolving drug for cholesterol gallstones.
  • To assess the safety and efficacy of GS-100 in patients with gallstones and bile duct stones.

Main Methods:

  • GS-100 was developed by supplementing d-limonene with 30% medium-chain monoglyceride (MCM).
  • The drug was administered to 23 patients with gallbladder stones and three with bile duct stones.

Related Experiment Videos

  • Stone composition was presumptively analyzed using CT recordings.

    • Main Results:

    • GS-100 demonstrated strong dissolution properties for cholesterol gallstones.
    • The treatment was applied to patients with both gallbladder and bile duct stones.
    • Preliminary results suggest GS-100 is superior to existing therapies in safety and application.

    Conclusions:

    • GS-100 represents a promising new option for non-invasive gallstone therapy.
    • Its enhanced safety profile and efficacy warrant further investigation.
    • GS-100 may become a significant therapeutic agent for gallstone treatment in the future.