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Serotype distribution, antimicrobial susceptibility, and clinical character of Streptococcus pneumoniae isolates
1Department of Microbiology, College of Medicine and Allied Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Abstract:
Strains of Streptococcus pneumoniae (268 in toto) isolated from different infected sites in patients were serotyped, their susceptibilities to antimicrobial agents were determined, and the laboratory data were correlated with clinical information. The distribution pattern of serogroups and serotypes was different in paediatric patients (< 18 years old) when compared with that of adults. Overall, 91% of the strains were represented in a 23-valent vaccine. Only eight patients received pneumococcal vaccine before infection, and only 18 strains (6.7%) were moderately susceptible or resistant to one or more of the antimicrobial agents tested. Five strains were moderately susceptible to penicillin G, and not one was fully resistant.
Insights
This study analyzed Streptococcus pneumoniae strains from patients, finding most were covered by a 23-valent vaccine. Antimicrobial resistance was low, with no strains fully resistant to penicillin G.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Vaccinology
Background:
- Streptococcus pneumoniae is a leading cause of bacterial infections globally.
- Understanding serotype distribution and antimicrobial susceptibility is crucial for effective prevention and treatment.
Purpose of the Study:
- To serotype Streptococcus pneumoniae strains from infected patients.
- To determine antimicrobial susceptibility patterns.
- To correlate laboratory findings with clinical information.
Main Methods:
- Serotyping of 268 Streptococcus pneumoniae isolates.
- Antimicrobial susceptibility testing using various agents.
- Comparison of serotype distribution between pediatric and adult patients.
Main Results:
- Serogroup and serotype distribution differed between pediatric and adult patients.
- 91% of isolates were covered by a 23-valent pneumococcal vaccine.
- Low rates of antimicrobial resistance observed; only 6.7% of strains showed moderate susceptibility or resistance to tested agents.
- No strains were fully resistant to penicillin G.
Conclusions:
- The 23-valent pneumococcal vaccine covers a high proportion of circulating Streptococcus pneumoniae strains.
- Antimicrobial resistance, particularly to penicillin G, remains low in the studied isolates.
- Distinct serotype patterns in pediatric versus adult populations warrant consideration for targeted vaccination strategies.