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A facility for biomedical experiments with thermal neutrons

O A Pettersson1, S N Chiangmai, E Grusell

  • 1Department of Radiation Sciences, Uppsala University, Sweden.

Physics in Medicine and Biology
|August 1, 1993
PubMed
Summary

The Studsvik thermal-neutron facility was modified for biological research, enabling cell and animal irradiation. Monte Carlo simulations confirmed low fast-neutron contamination, validating its suitability for biological applications.

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Area of Science:

  • Nuclear Physics
  • Radiation Biology
  • Medical Physics

Background:

  • The Studsvik thermal-neutron facility was initially designed for neutron capture radiography (NCR).
  • Modifications allow for in-situ irradiation of living cells and animals, eliminating reactor downtime.
  • Previous neutron intensity calculations relied on 2D diffusion theory (DIXY).

Purpose of the Study:

  • To validate the modified thermal-neutron facility for biological research using Monte Carlo simulations.
  • To accurately calculate neutron and photon fluences at irradiation positions.
  • To assess the facility's suitability for biological experiments, including cell survival studies.

Main Methods:

  • Utilized the Monte Carlo N-Particle (MCNP) 3B program for neutron transport calculations.

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  • Calculated neutron and photon fluences at radiography and cell specimen positions.
  • Irradiated V79 cells in monolayers with and without boron in the thermal neutron beam.

    • Main Results:

    • Monte Carlo calculations of neutron fluences closely matched measured values.
    • Calculated and measured photon doses showed reasonable agreement.
    • The thermal-neutron fluence rate was determined to be (2.3 ± 0.1) x 10^9 cm^-2 s^-1 at the NCR position (100 kW).
    • High-energy neutron contamination was found to be low.

    Conclusions:

    • The MCNP 3B simulations validate the modified Studsvik thermal-neutron facility for biological applications.
    • The facility provides a low fast-neutron contamination environment suitable for irradiating living cells and animals.
    • Experimental data on V79 cell survival curves are presented for further research.