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Related Experiment Videos

Skin stretching and epidermopoiesis

A J Francis, R Marks

    British Journal of Experimental Pathology
    |February 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Skin stretching alone does not cause epidermal hyperplasia. While stretch may increase the germinative cell pool, other factors likely drive the epidermal thickening observed over dermal lesions.

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    Area of Science:

    • Dermatology
    • Tissue Engineering
    • Cell Biology

    Background:

    • Epidermal hyperplasia is observed over dermal expansile lesions.
    • The role of mechanical stretch in this process is not fully understood.

    Purpose of the Study:

    • To investigate whether mechanical stretch alone can induce epidermal hyperplasia.
    • To differentiate the effects of stretch from other factors in lesion-induced skin changes.

    Main Methods:

    • Silastic materials were implanted into guinea-pig dermis to induce skin stretching.
    • Thymidine autoradiography was used to assess cell proliferation.
    • Epidermal thickness was measured to evaluate hyperplasia.

    Main Results:

    • Silastic elastomer implantation caused inflammation, confounding stretch-alone analysis.

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  • Silastic testicular implants, which did not cause inflammation, initially increased thymidine labelling index.
  • No significant increase in epidermal thickness was observed with Silastic testicular implants.

    • Conclusions:

    • Mechanical stretch may expand the epidermal germinative cell pool.
    • Epidermal hyperplasia over dermal lesions is likely mediated by factors beyond simple mechanical stretch.