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Updated: Aug 11, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
[Pharmacokinetics of muscone in rats, rabbits and dogs]
1Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Abstract:
The plasma concentration--time course of muscone in rats after a single i.v. administration fitted well to a two-compartment open model, and those in rabbits and dogs were all conformed to a three- compartment open model. Significant species differences were observed in the pharmacokinetic parameters among rats, rabbits and dogs, while no significant differences were found among the three dosages of 12, 18 and 24 mg/kg after i.v. administration to rats. In rats, the T1/2 beta was found to be 118.1-131.2 min. In rabbits and dogs, the T1/2 beta were 24.9 and 30.0 min, respectively and the T1/2 gamma were 331.9 and 366.4 min, respectively. In rats, rabbits and dogs, the Vss were 23.0, 51.7 and 7.3 L/kg, respectively, and the Vc were 2.33, 2.13 and 0.38 L/kg, respectively.
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