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Methods for evaluation of anti-asthma drugs in the primate
1Preclinical Research, Sandoz Pharma AG, Basel, Switzerland.
Abstract:
Use of the primate is gaining popularity in the definition of anti-asthma drugs. The present report describes three novel tests of (1) bronchodilatation, (2) hyperreactivity and (3) anti-inflammatory activity in the rhesus monkey. All tests are based on standard clinical techniques and the relevance and application of the tests to subsequent clinical evaluation is addressed.