Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relationship between capillary and systemic venous PO2 during nonhypoxic and hypoxic ventilation

J C Stein1, C G Ellis, M L Ellsworth

  • 1Department of Pharmacological and Physiological Science, St. Louis University School of Medicine, Missouri 63104.

The American Journal of Physiology
|August 1, 1993
PubMed
Summary

Systemic venous oxygen partial pressure (PO2) does not reliably estimate tissue oxygenation in hamster muscles. Only during acute hypoxia was there a correlation, suggesting arteriovenous shunting during normal ventilation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acceptability of high-resolution anoscopy for anal cancer screening in HIV-infected patients.

HIV medicine·2018
Same author

Role of erythrocyte-released ATP in the regulation of microvascular oxygen supply in skeletal muscle.

Acta physiologica (Oxford, England)·2015
Same author

Transformation of Brassica oleracea with an S-locus gene from B. campestris changes the self-incompatibility phenotype.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Simvastatin and GGTI-2133, a geranylgeranyl transferase inhibitor, increase erythrocyte deformability but reduce low O(2) tension-induced ATP release.

American journal of physiology. Heart and circulatory physiology·2013
Same author

Mass Transfer in a Rigid Tube With Pulsatile Flow and Constant Wall Concentration.

Journal of fluids engineering·2011
Same author

The Rho kinase inhibitor Y-27632 increases erythrocyte deformability and low oxygen tension-induced ATP release.

American journal of physiology. Heart and circulatory physiology·2011

Area of Science:

  • Physiology
  • Microcirculation
  • Tissue Oxygenation

Background:

  • Assessing tissue oxygenation is crucial for understanding cellular function and disease.
  • Systemic venous oxygen partial pressure (PO2) is a potential, non-invasive indicator of tissue oxygenation.
  • However, the direct relationship between systemic venous PO2 and end-capillary PO2 requires further investigation.

Purpose of the Study:

  • To evaluate the relationship between end-capillary PO2 and systemic venous PO2 in hamster retractor muscle.
  • To determine if systemic venous PO2 reliably estimates tissue oxygenation under varying ventilation conditions.
  • To investigate the potential presence of arteriovenous shunting of oxygen.

Main Methods:

  • In vivo video microscopy and computer-aided image analysis to measure oxygen saturation at the venular end of capillaries.

Related Experiment Videos

  • Measurement of systemic arterial and venous blood gases.
  • Use of an oxygen microelectrode to determine PO2 in first-order venules.
  • Experiments conducted under nonhypoxic and hypoxic ventilation with varying inspired oxygen levels (0.3, 0.21, 0.1).

    • Main Results:

    • A correlation between systemic venous PO2 and end-capillary PO2 was observed only during acute hypoxia.
    • No consistent relationship was found between these parameters during nonhypoxic ventilation.
    • Data support the hypothesis of arteriovenous shunting of oxygen during nonhypoxic conditions.

    Conclusions:

    • Systemic venous PO2 is not a reliable indicator of tissue oxygenation in hamster muscle under nonhypoxic conditions.
    • Acute hypoxia is necessary for systemic venous PO2 to reflect end-capillary PO2.
    • The findings suggest significant arteriovenous shunting of oxygen occurs during normal physiological states.