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Localized periorbital edema induced by aspirin
1Allergy and Immunology Unit, Assaf Harofeh Medical Center, Zerifin, Israel.
Allergy
|July 1, 1993
Summary
Localized swelling around the eyes in aspirin-sensitive patients may be histamine-related. Pretreatment with terfenadine can prevent these aspirin-induced skin reactions, but caution is advised.
Area of Science:
- Pharmacology
- Dermatology
- Allergy Immunology
Background:
- Aspirin sensitivity can manifest in various ways.
- Periorbital edema is a less common reaction.
- Distinguishing aspirin-induced reactions from other conditions like chronic urticaria is crucial.
Observation:
- Two patients presented with localized periorbital edema after ingesting low-dose aspirin (62.5-125 mg).
- Reactions occurred within 30 minutes, without systemic symptoms.
- Other nonsteroidal anti-inflammatory drugs (NSAIDs) did not trigger reactions in these patients.
Findings:
- Patients tolerated aspirin when pretreated with terfenadine, an antihistamine.
- These findings suggest a significant role for histamine in aspirin-induced periorbital edema.
- The reaction appears specific to aspirin and not other NSAIDs.
Implications:
- Histamine blockade may be a viable strategy for managing aspirin-induced skin reactions.
- This approach warrants caution and should be reserved for cases where aspirin is essential.
- Further research into the mechanisms of aspirin sensitivity and histamine pathways is indicated.