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Circadian variations of superoxide dismutase activity in the rat pineal gland
J Cipolla-Neto1, D S Abdalla, R P Markus
1Department of Physiology and Biophysics, Universidade de São Paulo, Brazil.
Journal of Neural Transmission. General Section
|January 1, 1993
Abstract:
The 24 h profile of the activity of the antioxidant enzyme superoxide dismutase (SOD) in the pineal gland of rats was studied. Rhythmic analysis showed a significant 24 h rhythm with an amplitude of oscillation of 25% of the 24 h mean value, that was 100.34 +/- 1.6 U SOD (nitrite). An ultradian rhythm of 9 h was also detected. The diurnal profile of superoxide dismutase activity is discussed in relation to the oxidative metabolism of the pineal gland.