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Updated: Jul 27, 2026

Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats
Published on: October 1, 2007
Vitamin E attenuates the development of haloperidol-induced dopaminergic hypersensitivity in rats: possible
W F Gattaz1, A Emrich, S Behrens
1Unit Neurobiology of Functional Psychoses, Central Institute of Mental Health, Mannheim, Federal Republic of Germany.
Abstract:
Chronic haloperidol treatment in rats results in behavioural supersensitivity to dopamine agonists. This mechanism has been suggested as a possible animal model for tardive dyskinesia. In the present study the simultaneous administration of vitamin E to chronic haloperidol treatment in rats prevented the development of behavioural supersensitivity to apomorphine. This finding suggest that the concomitant administration of vitamin E to neuroleptics might prevent the development of tardive dyskinesia in humans.
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