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Related Experiment Videos

Calibrators and control samples for bilirubinometers

B G Blijenberg1, G Brügmann, W J Geilenkeuser

  • 1Centraal Klinisch-Chemisch Laboratorium, Academisch Ziekenhuis Rotterdam-Dijkzigt.

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
|June 1, 1993
PubMed
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Calibration errors in bilirubinometers can be reduced by using specific control samples. These samples must have bilirubin concentrations between 230-300 mumol/l and match reference method values for accurate bilirubinometer calibration.

Area of Science:

  • Clinical Chemistry
  • Medical Laboratory Science

Background:

  • Neonatal serum and commercial controls present matrix challenges for bilirubinometer calibration.
  • Existing calibration methods using adult serum are often impractical for routine labs.

Purpose of the Study:

  • To establish preconditions for using control samples as calibrators for bilirubinometers.
  • To ensure accurate bilirubin measurements in clinical settings.

Main Methods:

  • Determined bilirubin concentrations in 16 control samples using reference methods and calibrated bilirubinometers/spectrophotometers.
  • Conducted interlaboratory surveys involving up to 72 laboratories.

Main Results:

  • Control samples are suitable calibrators if their bilirubin values align with reference methods.

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  • Optimal bilirubin concentration range for calibrators is 230-300 mumol/l.
  • Values above 300 mumol/l are unreliable due to limited linear range of bilirubinometers.

    • Conclusions:

    • Validated control samples meeting specific criteria can be used for bilirubinometer calibration.
    • This approach offers a practical alternative for routine laboratories.
    • Ensures reliable bilirubin measurements, crucial for patient diagnosis and management.