Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Explaining glomerular pores with fiber matrices. A visualization study based on computer modeling

J W Booth1, C J Lumsden

  • 1Membrane Biology Group, Department of Medicine, University of Toronto, Canada.

Biophysical Journal
|June 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment-limiting renal tubulopathy in patients treated with tenofovir disoproxil fumarate.

The Journal of infection·2017
Same author

Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cells.

Clinical and experimental immunology·2009
Same author

Membrane dynamics in phagocytosis.

Seminars in immunology·2001
Same author

Inherited neurodegenerative diseases: the one-hit model of neurodegeneration.

Human molecular genetics·2001
Same author

Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis.

The Journal of cell biology·2001
Same author

A one-hit model of cell death in inherited neuronal degenerations.

Nature·2000
Same journal

Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

Biophysical journal·2026
Same journal

Anisotropic unbinding and location-dependent hovering of a kinesin motor head over microtubule.

Biophysical journal·2026
Same journal

Kinesin-5/Cut7 C-terminal tail phosphorylation influence on motor regulation through multi-scale molecular modeling.

Biophysical journal·2026
Same journal

Dynamic conformations of fluorophores on self-labeling protein tags.

Biophysical journal·2026
Same journal

Different actions of RyR2 open and closed channel block explained by a multiscale Ca<sup>2+</sup> release model.

Biophysical journal·2026
Same journal

Membrane Environment Sets the Functional pK<sub>a</sub> of Ionizable Lipids.

Biophysical journal·2026
See all related articles

Glomerular ultrafiltration arises from a complex fiber matrix with a "blob-and-throat" structure. This matrix exhibits size-selective gating, explaining how the kidney filters solutes based on their radius.

Area of Science:

  • Biophysics
  • Renal Physiology

Background:

  • The glomerular capillary wall's extracellular space is a fibrous matrix.
  • Understanding its role in ultrafiltration and size/charge selectivity is crucial.

Purpose of the Study:

  • To investigate how the glomerular fiber matrix contributes to size recognition during ultrafiltration.
  • To model the void volume and permeation pathways within this matrix.

Main Methods:

  • Computer-generated 3D homogeneous random fiber matrices were created.
  • Void volume accessibility to hard spheres was visualized to analyze spatial organization.

Main Results:

  • The void volume exhibited a

Conclusions:

Related Experiment Videos

  • The glomerular fiber matrix possesses porelike properties due to its "blob-and-throat" structure.
  • This structure explains the observed size-selective filtration and the utility of pore models in understanding permselectivity.