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Related Experiment Videos

Two simple methods for measuring iodine in urine

J T Dunn1, H E Crutchfield, R Gutekunst

  • 1Department of Medicine, University of Virginia School of Medicine, Charlottesville.

Thyroid : Official Journal of the American Thyroid Association
|January 1, 1993
PubMed
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Iodine deficiency in the world: where do we stand at the turn of the century?

Thyroid : official journal of the American Thyroid Association·2001

New methods for measuring urinary iodine levels offer a fast, affordable way to assess iodine deficiency. These simple techniques are ideal for large-scale studies in developing nations.

Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Public Health

Background:

  • Urinary iodine excretion is a key indicator of iodine status.
  • International efforts to address iodine deficiency require efficient assessment tools.

Purpose of the Study:

  • To develop and validate rapid, cost-effective methods for measuring urinary iodine.
  • To adapt the Sandell-Kolthoff reaction for routine iodine assessment.

Main Methods:

  • Two adaptations of the Sandell-Kolthoff reaction were developed using chloric acid digestion.
  • Method A utilized a colorimeter, while Method B employed ferroin and a stopwatch.
  • Urine samples were analyzed for iodine concentration via catalytic reduction.

Main Results:

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  • The developed methods showed good agreement with a reference laboratory (9.1% and 15.7% difference).
  • Each method is capable of processing at least 150 tests daily per technician.
  • The cost per test is less than $0.50.

Conclusions:

  • The described methods are rapid, simple, and economical for assessing iodine deficiency.
  • These techniques are suitable for widespread epidemiological studies, particularly in resource-limited settings.
  • The adaptations facilitate monitoring and intervention for iodine deficiency disorders.