A comparative study of age-related changes in inhibitory processes and long-term potentiation in the lateral septum...

Anaesthetized C57 BL/6 mice of different ages (young: 5 months; middle-aged: 15 months; and old: 21 months) were used to determine whether aging alters the efficiency of synaptic inhibition and long-term potentiation (LTP) in the lateral septum (LS). Electrical stimulation of the fimbria induced field potentials in the ipsilateral LS comprising two initial negative components (N2 and N3) followed by a positive wave of low amplitude. Paired-pulse experiments showed a facilitation of the N2 component and a concomitant depression of the N3 components. Facilitation of the N2 component was stronger in both middle-aged and old mice as compared to young mice, whereas an inverse pattern of changes was observed for inhibition of the N3 component. High-frequency stimulation of the fimbria produced a persistent increase in the N3 amplitude. This LTP was of significantly higher amplitude in both young and middle-aged mice as compared to old mice. These results suggest that aging impairs both inhibitory processes and synaptic plasticity in the mouse LS, but that inhibitory processes appear to be affected earlier.