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Synthesis of the monodeoxy derivatives of 2-(trimethylsilyl)ethyl beta-lactoside
1Lund Institute of Technology, University of Lund, Sweden.
Carbohydrate Research
|August 17, 1993
Abstract:
Monodeoxy derivatives of 2-(trimethylsilyl)ethyl (Me3SiEt) beta-lactoside were synthesized, by deoxygenation at the disaccharide level, for the 2'-, 3'-, 4'-, and 6'-monodeoxylactosides. The 2-, 3-, and 6-deoxy derivatives were synthesized by beta-D-galactosylation of suitably protected monodeoxygenated Me3SiEt glucosides. Silver silicate was shown to be an efficient glycosylation promoter in the preparation of the 2- and 3-deoxylactosides.