Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The gastrointestinal mucosal immune system

S P James1

  • 1Department of Medicine, Baltimore VA Medical Center, Md.

Digestive Diseases (Basel, Switzerland)
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mosquitoes and Malaria in England.

The Hospital and health review·2018
Same author

Collection of Mosquitos and Their Larvæ.

The Indian medical gazette·2017
Same author

Extermination of Mosquitos.

The Indian medical gazette·2017
Same author

Remarks on the Differential Count of the Leucocytes in Malarial and Other Fevers of India.

The Indian medical gazette·2017
Same author

On the Metamorphosis of the Filaria Nocturna in Mosquitos of the <i>Anopheles</i> Genus.

The Indian medical gazette·2017
Same author

Mosquitos and Malaria.

The Indian medical gazette·2017
Same journal

Pancreatitis in Familial Dysautonomia Patients.

Digestive diseases (Basel, Switzerland)·2026
Same journal

Treatment outcomes with empirical Clarithromycin-based triple therapy for Helicobacter pylori in Zambia, sub-Saharan Africa.

Digestive diseases (Basel, Switzerland)·2026
Same journal

Endoscopic submucosal dissection-associated bacteremia: proper antibiotic management.

Digestive diseases (Basel, Switzerland)·2026
Same journal

The investigation and treatment of Helicobacter pylori for the prevention of gastric cancer: A narrative review and assessment of management approaches.

Digestive diseases (Basel, Switzerland)·2026
Same journal

Analysis of Helicobacter pylori resistance and its trends in Chongqing: A 10-year retrospective study.

Digestive diseases (Basel, Switzerland)·2026
Same journal

Early-onset colorectal cancer in Australia: environmental, microbial, and policy implications.

Digestive diseases (Basel, Switzerland)·2026
See all related articles

The mucosal immune system, primarily in the gut, uses specialized structures and cells like IgA B cells to defend against pathogens while tolerating food and microbes. This system is crucial for maintaining gut health and immune balance.

Area of Science:

  • Immunology
  • Gastroenterology

Background:

  • The mucosal immune system is the body's largest immune compartment, located in tracts like the gastrointestinal system.
  • It possesses unique features for initiating and regulating immune responses.

Purpose of the Study:

  • To describe the key characteristics of the gastrointestinal mucosal immune system.
  • To explain its role in balancing pathogen defense with tolerance.

Main Methods:

  • Review of existing literature on mucosal immunology.
  • Analysis of specialized structures and cellular components.

Main Results:

  • The gastrointestinal mucosal immune system includes Peyer's patches for immune initiation.
  • Specific lymphocyte recirculation (mucosal homing) and predominant IgA B cells and memory T cells are key features.

Related Experiment Videos

  • Secretory IgA is the main immunoglobulin, adapted for mucosal defense.

    • Conclusions:

    • The gastrointestinal mucosal immune system effectively protects against pathogens.
    • It maintains tolerance to dietary antigens and commensal microbiota.
    • These functions are critical for overall host health and immune homeostasis.