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Related Experiment Videos

Direct 31P imaging in human limb and brain

T Ernst1, J H Lee, B D Ross

  • 1Huntington Medical Research Institutes, Pasadena, CA 91105.

Journal of Computer Assisted Tomography
|September 1, 1993
PubMed
Summary

Direct imaging of phosphorus metabolites like phosphocreatine (PCr) and inorganic phosphate (Pi) in human brain and muscle is now possible. This technique aids in diagnosing conditions like peripheral ischemia and brain pathologies.

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Area of Science:

  • Biomedical Imaging
  • Phosphorus Magnetic Resonance Spectroscopy (31P MRS)
  • Metabolic Imaging

Background:

  • Phosphorus metabolites such as phosphocreatine (PCr) and inorganic phosphate (Pi) are crucial indicators of cellular energy status.
  • Direct imaging of these metabolites in vivo has been challenging.

Purpose of the Study:

  • To describe and validate two methods for direct imaging of PCr and Pi in human brain and muscle.
  • To assess the clinical utility of these imaging techniques.

Main Methods:

  • Utilized a 1.5 T whole-body scanner with 31P and 1H resonators.
  • Employed a multiple slice, multiple echo imaging sequence.
  • Achieved PCr signal selection via selective excitation or chemical shift artifact.

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Main Results:

  • Demonstrated uniform PCr distribution in normal muscle, with deficits corresponding to anatomical structures.
  • Observed selective PCr loss and Pi increase in muscle during exercise, more pronounced in diabetic patients.
  • Successfully imaged PCr in the human brain, showing uniform distribution in the cortex and deficits in tumors.

Conclusions:

  • Direct imaging of PCr and Pi is effective in human brain and limb.
  • The described methods promise improved fast phosphorus imaging.
  • Anticipated clinical utility for peripheral ischemia and localized brain energy deficits in various pathologies.