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Human thyroid tissue do not express thyroalbumin

H M Targovnik¹, G D Frechtel, V Varela

¹Catedra de Genética y Biología Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.

Journal of Endocrinological Investigation

|June 1, 1993

Summary

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Thyroid tissue does not produce albumin. Instead, albumin is likely absorbed from the bloodstream, iodinated by thyroid cells, and then released back into circulation.

Area of Science:

Biochemistry
Molecular Biology
Endocrinology

Background:

Multinodular goiter (G2) and hereditary goiter with defective thyroglobulin (Tg) synthesis (JNA) are thyroid conditions.
JNA is characterized by a near absence of Tg and the presence of an albumin-like protein in thyroid tissue.

Purpose of the Study:

To investigate the presence of albumin transcripts in thyroid tissue from patients with goiter.
To determine if thyroid cells synthesize albumin.

Main Methods:

Northern blot and dot-blot analyses using albumin cDNA probes on total RNA from G2 and JNA thyroid tissues.
Polymerase Chain Reaction (PCR) amplification of total RNA from JNA and control thyroid tissues using albumin and Tg primers.

Main Results:

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No hybridization signal for albumin was detected in G2 and JNA thyroid tissues by Northern blot or dot-blot analysis.
PCR analysis confirmed the absence of albumin amplification products in JNA and control thyroid tissues, while a liver sample showed a positive result.

Conclusions:

Thyroid cells do not contain the albumin transcript, indicating they do not synthesize albumin.
Albumin is likely taken up from circulation, iodinated by thyroid follicular cells, and released as iodoalbumin.