Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pathogenesis on infertility; its immunological aspects]

Y Yagami1

  • 1Department of Obstetrics and Gynecology, Nagoya City University Medical School.

Nihon Sanka Fujinka Gakkai Zasshi
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti beta 2glycoprotein I antibodies and lupus anticoagulant in patients with recurrent pregnancy loss: prevalence and clinical significance.

Lupus·1996
Same author

Laparoscopic-assisted creation of a vagina.

The Journal of the American Association of Gynecologic Laparoscopists·1996
Same author

Are antinuclear antibodies predictive of recurrent miscarriage?

Lancet (London, England)·1996
Same author

beta 2-Glycoprotein I-dependent anticardiolipin antibodies as a predictor of adverse pregnancy outcomes in healthy pregnant women.

Human reproduction (Oxford, England)·1996
Same author

Diagnosis of fetal rubella infection with reverse transcription and nested polymerase chain reaction: a study of 34 cases diagnosed in fetuses.

American journal of obstetrics and gynecology·1996
Same author

Human pregnancy serum suppresses the proliferative response of lymphocytes to autologous PHA-activated T lymphoblasts.

American journal of reproductive immunology (New York, N.Y. : 1989)·1996
Same journal

[A case of fibrosarcoma of the ovary].

Nihon Sanka Fujinka Gakkai zasshi·1996
Same journal

[Ovarian cancer with prior gynecological laparotomy].

Nihon Sanka Fujinka Gakkai zasshi·1996
Same journal

[Clinical and histopathologic features of the uterine lipoleiomyoma].

Nihon Sanka Fujinka Gakkai zasshi·1996
Same journal

[A case of peritonitis with systemic lupus erythematosus].

Nihon Sanka Fujinka Gakkai zasshi·1996
Same journal

Attempt to continue pregnancy of remaining fetuses after delivery of preceding fetus in multiple pregnancies before 24 weeks gestation: report of three cases.

Nihon Sanka Fujinka Gakkai zasshi·1996
Same journal

[Findings of uterine sarcoma and uterine myoma by color and power Doppler].

Nihon Sanka Fujinka Gakkai zasshi·1996
See all related articles

This study investigates the immunologic causes of infertility, focusing on autoimmune antiphospholipid antibodies (aPL) and alloimmune factors. It suggests IgG-aPL is a useful marker for infertility and that combined immunosuppressive and anticoagulant therapy can be effective for aPL-positive pregnancies.

Area of Science:

  • Reproductive Immunology
  • Immunopathology
  • Maternal-Fetal Medicine

Context:

  • Infertility affects many couples, with a significant portion remaining unexplained.
  • Immunologic factors, both autoimmune and alloimmune, are increasingly implicated in reproductive disorders.
  • Understanding these immunologic mechanisms is crucial for effective infertility management.

Purpose:

  • To investigate the role of autoimmune antiphospholipid antibodies (aPL) in infertility.
  • To explore alloimmune abnormalities that may contribute to pregnancy loss.
  • To assess the diagnostic and therapeutic implications of these immunologic findings.

Summary:

  • Autoimmune evaluation identified IgG-aPL as a potential diagnostic and prognostic marker in infertility, possibly causing pregnancy loss via prostacyclin inhibition and placental vascular issues.

Related Experiment Videos

  • Alloimmune evaluation explored mechanisms of fetal allograft acceptance, including blocking antibodies.
  • Combined immunosuppressive and anticoagulant therapy showed efficacy in aPL-positive pregnancies.

    • Impact:

    • Highlights IgG-aPL as a key factor in unexplained infertility and recurrent pregnancy loss.
    • Suggests potential therapeutic strategies targeting immunologic dysfunction in infertility.
    • Advances understanding of maternal-fetal immune interactions in successful and unsuccessful pregnancies.