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Immune changes during short-duration missions

G R Taylor1

  • 1L.B. Johnson Space Center, Houston, TX 77058.

Journal of Leukocyte Biology
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

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Short space missions significantly impact immune function. Studies show spaceflight can suppress immune cell activity and alter immune cell populations post-flight, affecting cell-mediated immunity.

Area of Science:

  • Space immunology
  • Human physiology in spaceflight

Background:

  • Spaceflight profoundly affects immune mechanisms in humans and animals.
  • Previous research primarily compared pre-flight and post-flight immune data.

Purpose of the Study:

  • To examine the immunological effects of short-duration space missions (less than 1 month).
  • To review findings on immune system alterations during and after spaceflight.

Main Methods:

  • Analysis of astronaut immune cell populations and function before and after flight.
  • In vitro studies conducted during spaceflight.
  • Recent implementation of in-flight, in vivo, cell-mediated immunity data collection by US and Russian space programs.

Main Results:

Keywords:
NASA Center JSCNASA Discipline Number 18-10NASA Discipline Regulatory PhysiologyNASA Experiment Number AP002NASA Experiment Number AR-002NASA Program Space Physiology and Countermeasures

Related Experiment Videos

  • Short-duration missions can lead to post-flight immune suppression, including reduced blast cell transformation.
  • Significant alterations in cytokine function and immune cell distribution are observed.
  • In-flight data confirm a blunting of the human cell-mediated immune system during spaceflight.

    • Conclusions:

    • Spaceflight, even for short durations, materially influences the immune system.
    • In-flight, in vivo data collection is crucial for accurate assessment of immune responses during space missions.
    • The human cell-mediated immune system is demonstrably impaired during spaceflight.