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Is cholecystokinin the peptide that controls fat intake?
1E.W. Bourne Behavioral Research Laboratory, Department of Psychiatry, Cornell University Medical College, White Plains, NY 10605.
Nutrition Reviews
|June 1, 1993
Summary
Cholecystokinin (CCK) plays a role in reducing meal size after nutrient intake. However, recent findings suggest CCK
Area of Science:
- Gastroenterology and Nutrition
- Neuroendocrinology
Background:
- Cholecystokinin (CCK) is a gut hormone released after nutrient ingestion, particularly lipids.
- CCK is known to influence satiety and reduce food intake.
- CCK antagonists have been instrumental in studying its physiological roles.
Purpose of the Study:
- To investigate the role of Cholecystokinin (CCK) in regulating food intake.
- To clarify the function of CCK in mediating fat intake in humans.
Main Methods:
- Review of existing animal and human studies on CCK.
- Analysis of data from studies utilizing CCK antagonists.
- Evaluation of a recent report challenging CCK's role in human fat intake.
Main Results:
- Exogenous CCK administration consistently reduces meal size in animal models and humans.
- Animal studies strongly support CCK's importance in regulating fat consumption.
- A recent human study indicates CCK may not be crucial for fat intake mediation.
Conclusions:
- CCK is a significant regulator of meal size across species.
- The role of CCK in mediating fat intake might differ between humans and animals.
- Further research is needed to fully elucidate CCK's function in human appetite regulation.