Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The visual cortex during chronic stimulation

J M Harrison, W W Dawson

    Brain, Behavior and Evolution
    |February 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Electrical stimulation of cat brains reduced tissue impedance, linked to current and seizures, not electrode material. Mannitol offered no protection, while glucocorticoids prevented impedance decrease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Martin's Bandage.

    The Southern medical record·2022
    Same author

    The President's Address.

    The Dental register·2021
    Same author

    Risk of malignancy in small pancreatic cysts decreases over time.

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2020
    Same author

    An elevated CA 19-9 is associated with invasive cancer and worse survival in IPMN.

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2020
    Same author

    Comparison of Two Speech Processing Schemes Using Normal-hearing Subjects.

    Acta oto-laryngologica·2020
    Same author

    Flavonoid rich dark cocoa may improve fatigue in people with multiple sclerosis, yet has no effect on glycaemic response: An exploratory trial.

    Clinical nutrition ESPEN·2018
    Same journal

    "Mind Over Muscle": Neural and Biomechanical Signatures of Expertise in Early Stone Tool Use.

    Brain, behavior and evolution·2026
    Same journal

    A step forward in encephalization: the virtual endocast of the Middle Pleistocene hominin from Ceprano, Italy.

    Brain, behavior and evolution·2026
    Same journal

    Anatomical and Volumetric Description of the Baird's Beaked Whale (Berardius bairdii) brain from Magnetic Resonance Imaging.

    Brain, behavior and evolution·2026
    Same journal

    Immunohistochemical Staining of the Brain of the Tuatara Sphenodon punctatus.

    Brain, behavior and evolution·2026
    Same journal

    Macroevolutionary patterns of endocast lateralization in catarrhines and fossil hominins.

    Brain, behavior and evolution·2026
    Same journal

    Phylogenetic patterns and genomic correlates of pronounced neocortical reduction in New World monkeys.

    Brain, behavior and evolution·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Electrophysiology

    Background:

    • Electrical stimulation is a key tool in neuroscience research.
    • Understanding tissue impedance changes during stimulation is crucial for interpreting results and device safety.
    • The lateral and suprasylvian gyri are important cortical areas in feline brains.

    Purpose of the Study:

    • To investigate the effects of prolonged anodic electrical stimulation on feline cortical tissue impedance.
    • To determine the relationship between stimulation parameters, electrode materials, and impedance changes.
    • To explore the influence of pharmacological agents on stimulation-induced impedance modifications.

    Main Methods:

    • Anodic stimulation of cat lateral and suprasylvian gyri using biphasic square waves (40 h total).

    Related Experiment Videos

  • Utilized surface and concentric electrodes made of carbon, rhodium, platinum, and gold.
  • Measured tissue impedance changes in response to varying stimulus currents and seizure incidence.
  • Administered Mannitol and glucocorticoids systemically to assess their effects on impedance.

    • Main Results:

    • Significant reductions in tissue impedance were observed shortly after stimulation onset.
    • Impedance changes correlated with stimulus current intensity and the occurrence of motor seizures.
    • Electrode material (carbon, Rh, Pt, Au) did not show a clear effect on impedance reduction.
    • Impedance changes were not localized to the stimulating electrode-tissue interface when using concentric electrodes.
    • Systemic Mannitol did not prevent stimulation-associated impedance modifications.
    • Systemic glucocorticoids abolished the typical impedance decrease.

    Conclusions:

    • Prolonged electrical stimulation induces significant, non-localized tissue impedance changes in feline cortex.
    • Stimulus parameters and physiological responses (seizures) are key factors influencing impedance, rather than electrode material.
    • Glucocorticoids can modulate or prevent stimulation-induced impedance changes, suggesting a role for inflammatory or cellular processes.