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Related Experiment Videos

Spatial processing and emotionality in aged NMRI mice: a multivariate analysis

Y Lamberty1, A J Gower

  • 1UCB S.A., Pharma Sector, Chemin du Foriest, Braine-l'Alleud, Belgium.

Physiology & Behavior
|August 1, 1993
PubMed
Summary
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Aging NMRI mice show independent behavioral declines, except for links between open-field activity and spatial learning, and maze arm exploration and initial open-field activity.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Gerontology

Background:

  • Aging in mice (17 months) is associated with behavioral decline.
  • Specific deficits observed in spatial processing, fear/anxiety, and ambulation.

Purpose of the Study:

  • To investigate relationships between various age-related behavioral declines in NMRI mice.
  • To apply multivariate analysis to understand interdependencies of behavioral changes.

Main Methods:

  • Factor analysis of behavioral data.
  • Correlation analysis of variable factor scores.
  • Utilized Morris-type water maze, Y-maze, and elevated plus maze tests.

Main Results:

  • Age-related behavioral changes were largely independent.

Related Experiment Videos

  • A negative correlation was found between open-field activity (6 min) and Morris water maze performance.
  • Exploration of elevated plus maze arms correlated with initial open-field locomotor activity (2 min).

    • Conclusions:

    • Spatial learning and spontaneous alternation defects may involve distinct underlying mechanisms.
    • Locomotor activity in aged mice is context-dependent, reflecting different factors across tasks.