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Platelet aggregation induced by calceolarioside A in vitro: role of platelet intracellular calcium
A Capasso1, A Di Giannuario, S Pieretti
1Dipartimento di Farmacologia Sperimentale, Università degli Studi di Napoli Federico II, Italy.
Abstract:
The effect of calceolarioside A, a phenylpropanoid glycoside (PhG), isolated from Calceolaria hypericina, was studied on rabbit platelets in vitro. Calceolarioside A induced a dose-related aggregant effect on rabbit platelets. Indomethacin did not modify the calceolarioside A-induced aggregant effect. Furthermore, no modification was exerted by phenoxybenzamine, BW 577C, and WEB 2086 on the PhG aggregant effect. On the contrary, TMB-8, an intracellular calcium blocker, significantly reduced the PhG effect. The latter result suggests that calceolarioside A aggregation may be partly related to a calcium-dependent mechanism.