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Related Experiment Videos

Central actions of histamine: microelectrophoretic studies

H L Haas, P Wolf

    Brain Research
    |February 18, 1977
    PubMed
    Summary

    Histamine has a dual effect on brain neurons, exciting the hypothalamus while depressing others. This suggests histamine is a neurotransmitter in the mammalian brain, with effects blocked by H2-receptor antagonists.

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    Area of Science:

    • Neuroscience
    • Neuropharmacology

    Background:

    • Histamine is a biogenic amine found in the brain.
    • Its role in neuronal signaling is not fully understood.

    Purpose of the Study:

    • To investigate the effects of histamine on neuronal activity in various brain regions.
    • To explore the potential role of histamine as a neurotransmitter in the mammalian brain.

    Main Methods:

    • Micro-electrophoretic application of histamine and related substances to rat and cat brain neurons.
    • Administration of metiamide, an H2-receptor antagonist, to observe its effects.

    Main Results:

    • Histamine excited most hypothalamic neurons.
    • Histamine depressed neurons in most other brain structures studied.
    • Metiamide antagonized the depressant effects of histamine in the rat cortex and hippocampus.

    Conclusions:

    • Histamine exhibits differential effects on neuronal activity across brain regions.
    • The findings support the hypothesis of histaminergic neurotransmission in the mammalian brain.
    • H2-receptors are involved in mediating some of histamine's central nervous system effects.

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