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HLA-DR-specific suppressor cells after repeated allogeneic sensitizations of human lymphocytes in vitro

M Sasportes, D Fradelizi, J Dausset

    Transplantation Proceedings
    |December 1, 1978
    PubMed

    In conclusion, DR-specific suppressor cells can be induced by repeated in vitro sensitizations. They were able (1) to decrease a secondary proliferation, (2) to suppress consistently, in a primary proliferative assay, when added as third cells (primed twice against a DR antigen [PLT II] and gamma-irradiated), the response of unprimed cells towards stimulating cells, which share a DR specificity with the priming cell of the PLT II. The suppression follows the D part of the recombinant haplotype within an HLA-B/D recombinant family and is specific for the DR antigen used twice as stimulator for production of the PLT II.

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