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Variability in response to D-penicillamine: pharmacokinetic insights
1Department of Clinical Pharmacology, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands.
Agents and Actions. Supplements
|January 1, 1993
Abstract:
D-Penicillamine (D-Pen) is one of a group of chemically similar drugs which are efficacious in rheumatoid arthritis and which have similar patterns of biotransformation and similar toxicity. These similarities suggest associations between the transformations of D-Pen and it's toxicity and efficacy. Oxidation, methylation, formation of stable adducts with protein, interaction with metals and reduction of oxygen species have been shown in-vivo or in-vitro. Metabolism to a sulphoxide may occur and may be relevant to toxicity. Intracellular concentrations of D-Pen and metabolites are largely unknown.