Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variability in response to NSAIDs: what progress?

R O Day1

  • 1Department of Clinical Pharmacology, University of New South Wales, Australia.

Agents and Actions. Supplements
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying the association between tacrolimus exposure and toxicity in heart and lung transplant recipients: A systematic review.

Transplantation reviews (Orlando, Fla.)·2021
Same author

Trends, determinants and differences in antibiotic use in 68 residential aged care homes in Australia, 2014-2017: a longitudinal analysis of electronic health record data.

BMC health services research·2020
Same author

Towards precision dosing of vancomycin in critically ill patients: an evaluation of the predictive performance of pharmacometric models in ICU patients.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020
Same author

Towards precision dosing of vancomycin: a systematic evaluation of pharmacometric models for Bayesian forecasting.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
Same author

Evaluation of Clinical Relevance of Drug-Drug Interaction Alerts Prior to Implementation.

Applied clinical informatics·2018
Same author

Interrogation of a longitudinal, national pharmacy claims dataset to explore factors that predict the need for add-on therapy in older and socioeconomically disadvantaged Australians with type 2 diabetes mellitus patients (T2DM).

European journal of clinical pharmacology·2018
Same journal

Ro 45-2081, a TNF receptor fusion protein, prevents inflammatory responses in the airways.

Agents and actions. Supplements·1998
Same journal

Immunomodulation of Crohn's disease by interleukin-10.

Agents and actions. Supplements·1998
Same journal

Cartilage protective agent (CPA) Ro 32-3555, a new matrix metalloproteinase inhibitor for the treatment of rheumatoid arthritis.

Agents and actions. Supplements·1998
Same journal

Symposium new drugs for inflammatory, allergic and immunologic disease.

Agents and actions. Supplements·1998
Same journal

The complexity of the B7-CD28/CTLA-4 costimulatory pathway.

Agents and actions. Supplements·1998
Same journal

A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells.

Agents and actions. Supplements·1998
See all related articles

Individual responses to non-steroidal anti-inflammatory drugs (NSAIDs) vary significantly. Understanding this variability requires linking clinical outcomes to pharmacokinetic and pharmacodynamic mechanisms for better NSAID therapy.

Area of Science:

  • Pharmacology
  • Rheumatology
  • Pain Management

Background:

  • Variability in non-steroidal anti-inflammatory drug (NSAID) response identified in 1976 remains poorly understood.
  • Key questions persist regarding individual response variability, reproducibility, influence of musculoskeletal disorders, and underlying mechanisms.

Purpose of the Study:

  • To highlight the need for further research into the nature and importance of NSAID response variability.
  • To identify critical unanswered questions regarding NSAID efficacy and toxicity.
  • To emphasize the requirement for linking clinical responses to pharmacokinetic and pharmacodynamic factors.

Main Methods:

  • Review of existing data on NSAID efficacy and toxicity.
  • Analysis of the relationship between plasma NSAID concentrations and clinical outcomes (efficacy and toxicity).

Related Experiment Videos

  • Discussion of proposed mechanisms of action beyond prostaglandin synthesis inhibition.

    • Main Results:

    • A weak correlation exists between plasma NSAID concentration and efficacy across various pain states (RA, OA, acute pain).
    • The efficacy relationship with concentration may resemble a steep rectangular hyperbola.
    • Proposed mechanisms beyond prostaglandin inhibition lack rigorous linkage to individual patient responses.

    Conclusions:

    • Significant gaps remain in understanding NSAID response variability.
    • Pharmacokinetic and pharmacodynamic mechanisms require systematic investigation to explain individual differences in NSAID therapy.
    • Further research is crucial for optimizing NSAID treatment strategies and patient outcomes.