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Related Experiment Videos

Nasal blood flow

H M Druce1

  • 1Department of Internal Medicine, St. Louis University School of Medicine, Missouri.

Annals of Allergy
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Objective assessment of nasal blockage is now possible. Laser-Doppler velocimetry offers detailed insights into nasal microcirculation, aiding the study of allergic reactions and nasal obstruction pathophysiology.

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Area of Science:

  • Otolaryngology
  • Allergy and Immunology
  • Physiology

Background:

  • Nasal blockage assessment was historically subjective.
  • Objective methods like nasal airway resistance measurement are now available.
  • Understanding nasal blockage requires analyzing secretions, cellular infiltrates, and microcirculatory parameters.

Purpose of the Study:

  • To explore the pathophysiology of nasal blockage.
  • To detail the utility of laser-Doppler velocimetry in assessing nasal microcirculatory parameters.
  • To evaluate the nasal microvascular response to various stimuli.

Main Methods:

  • Laser-Doppler velocimetry (LDV) for measuring nasal mucosal blood flow.
  • Radioactive xenon washout as an alternative method.

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  • LDV allows measurement of blood flow, volume, red blood cell speed, and pulsatility.
  • Continuous monitoring of microcirculatory parameters over time.

    • Main Results:

    • Laser-Doppler velocimetry provides comprehensive microcirculatory data.
    • The technique enables continuous assessment of nasal microvascular responses.
    • Nasal microvascular responses to neurohormones, antigenic, and histamine challenges were assessed.

    Conclusions:

    • Objective assessment of nasal blockage components is crucial for understanding pathophysiology.
    • Laser-Doppler velocimetry is a valuable tool for detailed nasal microcirculation analysis.
    • This technique aids in evaluating the efficacy of treatments like antihistamines.