[Importance of systemic administration of pyrimidine after thermochemotherapy]

Warmed (47 degrees C) 5 to 10% glucose solution with the addition of 0.05 mg of noradrenaline (PTCT) was administered after chemotherapy (MMC 2-10 mg or CDDP 10 mg) into tumor feeding artery of liver tumors (17 cases) and pancreas tumors (8 cases). Efficacy was noted in 14 cases with liver tumor (14/17 82.3%) and in 4 cases with pancreas tumor (4/8 50%). The metastatic rate in the PTCT with systemic administration of pyrimidine (5-FU: 100-300 mg or FT-207: 1,000 mg) was 0% (0/10) compared with 45.5% in controls (5/11) (p = 0.023). Thus, systemic administration of 5-FU or FT-207 after thermochemotherapy can prevent distant metastasis.