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[Portal blood levels of 5-FU administered intraperitoneally]
K Kakizaki1, S Teshima, H Yamauchi
1Dept. of Surgery, Sendai National Hospital.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|August 1, 1993
Abstract:
Portal blood levels of 5-FU were measured after intraperitoneal administration of 15 mg/kg of 5-FU in two patients who had a bypass operation for unresectable pancreatic cancer. The portal concentration of 5-FU increased rapidly. Tmax was 8-11 minutes and Cmax was 29-31 micrograms/ml. The peripheral blood levels followed the portal levels. Also, AUC of the portal levels seemed to be higher than the peripheral levels. The direct instillation of 5-FU into the peritoneal cavity might offer an alternative means of achieving higher regional drug levels, such as intraperitoneal and intraportal levels, without enhanced systemic toxicity.