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The oxazolidinone antibacterial agent DuP 105 does not act on cell wall biosynthesis or on a beta-lactamase
R B Silverman1, N Tran, R K Sinha
1Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113.
Biochemical and Biophysical Research Communications
|September 15, 1993
Abstract:
(S)-3-(4-Methylsulfinylphenyl)-5-(acetamidomethyl)oxazolidinone (DuP 105; 1, R = CH3SO, R' = Ac), one of a new class of antibacterial agents, is shown to be devoid of inactivation and inhibitory properties toward bacterial cell wall biosynthesis and toward a beta-lactamase. This is consistent with the idea that this class of compounds acts by a route different from that of the beta-lactam antibiotics.