[Structure-function organization of the angiotensin II molecule. II. Reverse structural problem]

A number of modifications of the amido acids sequence of the peptide hormone angiotensin II leading to the hormone's analogues with restricted conformational properties are considered. The relative conformational energies for all the analogues were evaluated in conformations similar to the low-energy conformations of the native hormone. Presented is the comparative analysis of the spatial structures of the native hormone and its analogues.