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New quinoline derivatives: synthesis and evaluation for antiinflammatory and analgesic properties--Note II
L Savini1, P Massarelli, C Pellerano
1Dipartimento Farmaco Chimico Tecnologico, Università Banchi di Sotto, Siena, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|June 1, 1993
Abstract:
The synthesis of new halogenated series of 4-anilinoquinoline-3-carboxylic acids, N-[3-carboxyquinolyl(4)]anthranilic acids and their corresponding esters is reported. These have been obtained by reacting 4-chloro-3-carbethoxy-quinolines with variously substituted anilines and methyl anthranilate respectively. The synthesized compounds were tested for antiinflammatory and analgesic activities; some of them showed a good analgesic activity, sometimes higher than that of indomethacin, used as reference drug.