Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurotoxicity of antineoplastic agents

M Hussain1, A J Wozniak, M B Edelstein

  • 1Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201.

Critical Reviews in Oncology/Hematology
|February 1, 1993
PubMed
Summary

This review examines neurotoxicity from antineoplastic agents, highlighting factors like dose and schedule. Understanding and managing this side effect is crucial for cancer patient quality of life.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remote versus in-clinic cochlear implant programming during rehabilitation: clinical outcomes and patient perspectives.

Disability and rehabilitation. Assistive technology·2026
Same author

Global advances and future directions in lung cancer care: expert consensus and strategic priorities.

ESMO open·2026
Same author

Corrigendum to "Positive impact of early-probiotic administration on performance parameters, intestinal health and microbiota populations in broiler chickens" [Poultry Science, Volume 103/issue 12,104401].

Poultry science·2025
Same author

Analyzing optimal control techniques in a nonlinear fractional Rubella model with the Atangana-Baleanu derivative.

Computers in biology and medicine·2025
Same author

Real World Multi-centre UK Review of Nivolumab Monotherapy in Metastatic Endometrial Cancer With Mismatch Repair Deficiency During COVID-19.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

Ipsilateral motor pathways related to proximal upper limb function in tetraplegia.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025

Area of Science:

  • Oncology
  • Neuroscience
  • Pharmacology

Background:

  • Neurotoxicity is a significant concern with antineoplastic agents.
  • Patient quality of life is increasingly prioritized in cancer treatment.

Purpose of the Study:

  • To review the neurotoxicity associated with antineoplastic agents.
  • To provide updated information on neurotoxicity from cancer therapies.

Main Methods:

  • A comprehensive review of 400 articles, abstracts, and book chapters.
  • Selection of 190 representative sources for detailed analysis.

Main Results:

  • Dose, schedule, and route of administration are key determinants of neurotoxicity.
  • Detailed review includes vinca alkaloids, cisplatin, and biologic response modifiers.
  • Discusses neurotoxic effects of novel cancer therapies and investigational agents.

Conclusions:

  • Neurotoxicity significantly impacts short- and long-term quality of life for cancer patients.
  • Improved screening models, grading systems, and prospective evaluation are needed.
  • Better understanding of neurotoxicity is essential for managing cancer patient care.

Related Experiment Videos