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Neurotoxicity of antineoplastic agents
M Hussain1, A J Wozniak, M B Edelstein
1Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201.
Critical Reviews in Oncology/Hematology
|February 1, 1993
Summary
This review examines neurotoxicity from antineoplastic agents, highlighting factors like dose and schedule. Understanding and managing this side effect is crucial for cancer patient quality of life.
Area of Science:
- Oncology
- Neuroscience
- Pharmacology
Background:
- Neurotoxicity is a significant concern with antineoplastic agents.
- Patient quality of life is increasingly prioritized in cancer treatment.
Purpose of the Study:
- To review the neurotoxicity associated with antineoplastic agents.
- To provide updated information on neurotoxicity from cancer therapies.
Main Methods:
- A comprehensive review of 400 articles, abstracts, and book chapters.
- Selection of 190 representative sources for detailed analysis.
Main Results:
- Dose, schedule, and route of administration are key determinants of neurotoxicity.
- Detailed review includes vinca alkaloids, cisplatin, and biologic response modifiers.
- Discusses neurotoxic effects of novel cancer therapies and investigational agents.
Conclusions:
- Neurotoxicity significantly impacts short- and long-term quality of life for cancer patients.
- Improved screening models, grading systems, and prospective evaluation are needed.
- Better understanding of neurotoxicity is essential for managing cancer patient care.